Dr. James Thrall

PACS/VNA
MGH's Thrall reflects on 30 years in radiology
On February 1, Dr. James Thrall stepped down as chairman of the department of radiology at Massachusetts General Hospital (MGH), ending a 30-year career as one of the leading figures in radiology. In this exclusive article, Dr. Thrall reflects on the changes he's seen over the past 30 years in medical imaging.
February 25, 2013
2013 02 25 11 30 07 718 Thrall James 70
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Mammogram Patient
Womens Imaging
Mammo uptake among veterans on par with nonveterans
Female veterans are as likely to undergo screening mammography as nonveteran women.
Patient examples of SPECT/CT and PET/CT RECIP 1.0. (A) SPECT and PET maximum-intensity projection (MIP) images in 74-year-old man with mCRPC. Serum PSA level at baseline was 449 ng/mL and slightly increased to 525 ng/mL after two cycles of Lu-177 PSMA. Eastern Cooperative Oncology Group (ECOG) score was 2 at baseline and increased to 3 after 2 cycles. The patient was classified by readers as RECIP-progressive disease on both SPECT and PET. Overall survival was 4.7 months. Two cycles of Lu-177 PSMA were administered. (B) SPECT and PET MIP images in 74-year-old man with mCRPC. Serum PSA level was 231 ng/mL at baseline and decreased to 12.5 ng/mL after 2 cycles of Lu-177 PSMA. ECOG score was less than 2 at baseline and after 2 cycles of Lu-177 PSMA. The patient was classified by readers as RECIP-partial response on both SPECT and PET. Overall survival was 14.3 months. Four cycles of Lu-177 PSMA were administered.
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Patient examples of SPECT/CT and PET/CT RECIP 1.0. (A) SPECT and PET maximum-intensity projection (MIP) images in 74-year-old man with mCRPC. Serum PSA level at baseline was 449 ng/mL and slightly increased to 525 ng/mL after two cycles of Lu-177 PSMA. Eastern Cooperative Oncology Group (ECOG) score was 2 at baseline and increased to 3 after 2 cycles. The patient was classified by readers as RECIP-progressive disease on both SPECT and PET. Overall survival was 4.7 months. Two cycles of Lu-177 PSMA were administered. (B) SPECT and PET MIP images in 74-year-old man with mCRPC. Serum PSA level was 231 ng/mL at baseline and decreased to 12.5 ng/mL after 2 cycles of Lu-177 PSMA. ECOG score was less than 2 at baseline and after 2 cycles of Lu-177 PSMA. The patient was classified by readers as RECIP-partial response on both SPECT and PET. Overall survival was 14.3 months. Four cycles of Lu-177 PSMA were administered.
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Figure: Improved image quality with a generative adversarial network architecture for low- to high-field-strength image translation, called LowGAN. (A–C) Top: High-field-strength (3-T) and low-field-strength (64-mT) images and LowGAN outputs for a single participant across (A) fluid-attenuated inversion recovery (FLAIR), (B) T1-weighted (T1w), and (C) T2-weighted (T2w) contrasts. Bottom: Graphs demonstrate the structural similarity index (SSIM), peak signal-to-noise ratio (PSNR), normalized cross-correlation (NCC), and feature similarity index (FSIM) between high field strength and low field strength (64-mT) and high field strength and LowGAN outputs. a.u. = arbitrary units.****p ≤ 0.0001. Images and caption courtesy of Radiology and the RSNA.
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