Nicolau Beckmann, PhD, and Sarah-Rebecca Herrmann

MRI
Preclinical lung imaging offers effective evaluation of drug candidates
Drug discovery and development are arduous and costly endeavors, with nine in 10 drug candidates failing to gain approval. Preclinical imaging can help pharmaceutical companies more effectively evaluate drug candidates, in particular for respiratory diseases.
January 31, 2021
2021 01 28 21 23 8159 2021 02 01 Bruker 400
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Tracking and quantitative analysis of diaphragmatic motion and projected lung area (PLA) at dynamic chest radiography (DCR) in a 55-year-old healthy man during deep breathing. (A) Posteroanterior radiograph with purple and green lines indicating the right and left lateral diaphragm apices, respectively. (B) Graph of diaphragmatic motion (in millimeters; y-axis) over time (i.e., frame number; x-axis). The software tracked the position of the diaphragm apex at DCR to obtain these amplitude-time plots of diaphragmatic motion (right lung, purple; left lung, green). The dark blue line corresponds to the frame representing the end of inspiration; the light blue line corresponds to the frame representing the end of expiration. (C) Posteroanterior radiograph shows the PLA (outline), which is the area surrounded by the medial edge of the ribs, the diaphragm, and the edge of the mediastinum. (D) Graph of PLA (in millimeters squared; y-axis) over time (i.e., frame number; x-axis). The software automatically tracked the boundaries of the lung fields and obtained the time-varying curves of the bilateral lung field areas. The blue line corresponds to the frame representing the end of inspiration.
Digital X-Ray
Dynamic chest radiography effective for diagnosing COPD
The technique can serve as an alternative to pulmonary function tests for diagnosing chronic obstructive pulmonary disease (COPD).
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Tracking and quantitative analysis of diaphragmatic motion and projected lung area (PLA) at dynamic chest radiography (DCR) in a 55-year-old healthy man during deep breathing. (A) Posteroanterior radiograph with purple and green lines indicating the right and left lateral diaphragm apices, respectively. (B) Graph of diaphragmatic motion (in millimeters; y-axis) over time (i.e., frame number; x-axis). The software tracked the position of the diaphragm apex at DCR to obtain these amplitude-time plots of diaphragmatic motion (right lung, purple; left lung, green). The dark blue line corresponds to the frame representing the end of inspiration; the light blue line corresponds to the frame representing the end of expiration. (C) Posteroanterior radiograph shows the PLA (outline), which is the area surrounded by the medial edge of the ribs, the diaphragm, and the edge of the mediastinum. (D) Graph of PLA (in millimeters squared; y-axis) over time (i.e., frame number; x-axis). The software automatically tracked the boundaries of the lung fields and obtained the time-varying curves of the bilateral lung field areas. The blue line corresponds to the frame representing the end of inspiration.
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