Bronchial carcinoid tumors: importance of prognostic factors that influence patterns of recurrence and overall survival.
Gould PM, Bonner JA, Sawyer TE, Deschamps C, Lange CM, Li H
PURPOSE: To analyze bronchial carcinoid characteristics that might influence
patterns of disease recurrence and overall survival in patients with these
tumors. MATERIALS AND METHODS: In a retrospective review, the actuarial
rates of local relapse, regional relapse, and overall survival were determined
in patients who had undergone resection of bronchial carcinoid tumors.
The evaluable files for 87 patients (50 male, 37 female; age range, 15-82
years) who underwent resection of bronchial carcinoid cancer at the authors'
institution between 1980 and 1993 were reviewed for pathologic findings,
extent of disease, and recurrence patterns after surgery. RESULTS: The
actuarial 4-year overall survival, local control, and regional control
rates in the entire cohort of patients were 89%, 92%, and 94%, respectively.
Univariate analyses revealed that an atypical histologic pattern was the
only tumor-related factor that substantially affected local and regional
control. Atypical histologic pattern and tumor size were among the multiple
factors that independently affected overall survival. CONCLUSION: Atypical
histologic findings in patients who had undergone complete resection of
bronchial carcinoid tumors were associated with increased local-regional
disease recurrence and decreased survival compared with recurrence and
survival in patients with typical histologic findings.
