The cleanroom at NorthStar's campus in Beloit, WI.
Image courtesy of NorthStar
NorthStar Medical Radioisotopes has completed a cleanroom facility at its campus in Beloit, WI, to support batch production of radiopharmaceuticals for research and treatment.
The suite features specialized enclosures designed for safe and aseptic (contamination-free) preparation of sterile radioactive drug products, a work area within the cleanroom where operators can stage materials or weigh, adjust, and dissolve components used in the process, and a controlled entry.
The cleanroom at NorthStar's campus in Beloit, WI.Image courtesy of NorthStar
The suite will support both current clinical trials and full-scale radiopharmaceutical manufacturing that will commence in July when its new 52,000-sq-ft facility opens, the company said.
![Pittsburgh Compound B (PiB) PET distribution volume ratio (DVR) images were projected onto fsaverage surfaces from FreeSurfer and surface smoothed, with PiB (amyloid) slope maps created using ordinary least squares regression (time as only factor) and mixed effects models for 154 participants run at each vertex (P < .01; model: longitudinal Geriatric Depression Scale score estimated by amyloid slope × time + [sex + education + age] × time). This map visualizes the results of the linear mixed-effects models (t score of the main variable, amyloid slope × time) such that regions with a greater t score (red) represent areas in which greater depressive symptoms are associated with greater amyloid accumulation (amyloid slope). Anatomical landmarks are provided: L refers to the left hemisphere, R refers to the right hemisphere, and additional labels indicate the anterior and posterior ends of the brain. Images available for republishing under Creative Commons license (CC BY 4.0 DEED, Attribution 4.0 International) and courtesy of JAMA Open Network.](https://img.auntminnie.com/files/base/smg/all/image/2024/08/PET_depression.66cf997f7e441.png?auto=format%2Ccompress&dpr=2&fit=crop&h=167&q=70&w=250)
