The American College of Radiology Imaging Network (ACRIN) has begun a multicenter clinical trial to assess how cardiac CT angiography (CCTA) and SPECT affect outcomes in patients with stable angina.
The ACRIN 4701 trial, also known as RESCUE (Randomized Evaluation of Patients With Stable Angina Comparing Utilization of Noninvasive Examinations), will randomly assign study participants to either CCTA or SPECT myocardial perfusion imaging (MPI) for diagnosis of symptoms potentially related to coronary artery disease.
ACRIN said that the RESCUE trial will address the hypothesis that, in comparison with the SPECT-MPI study arm, the CCTA arm will not result in an increase of myocardial infarction, cardiac-related death, or revascularization; it also will reduce risk (e.g., less radiation exposure), provide additional insights into alternate explanations of chest pain, and be more cost-effective.
A total of 4,300 study participants will be enrolled at up to 80 institutions internationally, according to ACRIN. For more information, click here.
