J Cancer Res Clin Oncol 2000 Oct;126(10):560-74
Positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose in
oncology. Part II. The clinical value in detecting and staging primary tumours.
Ak I, Stokkel MP, Pauwels EK.
The tumoral uptake of 2-[18F]fluoro-2-deoxy-D-glucose (18FdGlc) is based upon
enhanced glycolysis. Positron-emission tomography (PET) using 18FdGlc provides
the physiological and metabolic information. 18FdGlc PET has been used
successfully for assessing primary tumours and metastases, prognosis, and
planning and for monitoring tumour therapy as well as for early detection of
recurrent tumour growth. This review summarises the uptake mechanism of 18FdGlc
in benign and malignant lesions, its relation to histopathology, and its
clinical value for detecting and staging primary tumours.
Publication Types:
- Review
