A new PET imaging agent based on a copper-64 isotope is showing promise that it can prevent the death of neurons and relieve symptoms of Parkinson's disease in animal models, according to a study published April 2 in the Journal of Experimental Medicine.
Researchers from the University of Melbourne, led by Dr. David Finkelstein, have found that CuII(ATSM) reverses the neurotoxicity that destroys dopamine-secreting neurons. Improvements in motor skills and memory also were noted after treatment in four unique animal models of Parkinson's disease.
The authors suggest the compound functions as a scavenger of peroxynitrite, which accumulates and can promote neuronal death.
These results point to a potential strategy to restore motor and cognitive function in Parkinson's disease patients by reviving neuronal function rather than solely masking symptoms.
