Autoimmune > Hyalinizing granuloma

Hyalinizing Granuloma

- Clinical:

Hyalinizing granuloma is an idiopathic condition that manifests with pulmonary nodules and masses that show concentric hyaline lamellae [1]. Several mechanisms have been proposed, including atypical immune response to mycobacterial or fungal antigens or burned out myofibroblastic tumors [1]. Affected patients are usually asymptomatic or can present with vague chest-related symptoms such as SOB, cough, fatigue, low grade fever, or pleuritic chest pain [1].

- X-ray:

Radiographs demonstrate bilateral large nodules or masses, which on CT tend to be randomly distributed and often contain calcium [1]. Pleural effusions and adenopathy are rare [1].

REFERENCES:

(1) Radiographics 2020; Naeem M, et al. Noninfectious granulomatous diseases of the chest. 40: 1003-1019

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