(Booth 227) Hologic will talk up recently published clinical papers that highlight the utility of computer-aided detection (CAD) in improving the accuracy of screening mammography.
An April 2008 study in the American Journal of Roentgenology used Hologic's R2 software as part of a large-scale breast screening trial that compared a single radiologist using CAD to double reading without CAD. The study compared recall rate, sensitivity, positive predictive value, and cancer detection rate, and found that R2 CAD increased sensitivity in cancer detection with only a small increase in recall rate, according to the Bedford, MA-based company.
In a New England Journal of Medicine study, U.K. researchers used R2 software in a multicenter trial comparing the cancer detection rates of screening with single reading and CAD to that of double reading. The group found that single reading with CAD produced a sensitivity of 87.2%, while double reading recorded a sensitivity of 87.7%. Single reading with CAD had a marginally higher recall rate of 3.9%, versus 3.4% for double reading.
